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Prof. Dr. Bernd Schmeck

Precision Medicine and Targeted Therapy of Inflammatory Diseases

Inflammatory diseases (allergy, autoimmunity, infection, partly malignancies ...) cause a significant morbidity and mortality. New targeted therapies addressing signalling pathways and cell-cell- communication show great promises, but only in specific patient subgroups.
Thus, there is an ongoing urgency for a more targeted and holistic management of the disease, incorporating experimental and clinical multi-OMICS data and the basic principles of P4 medicine (predictive, preventive, personalized, and participatory). I will address the current status and unmet needs regarding precision medicine for patients with inflammatory diseases.

Curriculum vitae

Date of Birth: 19.08.1974

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University Education

2007                   Habilitation, Humboldt-University Berlin

2002                   Dr. med., Humboldt-University Berlin

2000                   State examination in Medicine, Justus-Liebig-University Gießen and Humboldt-University Berlin

 

Employment and Positions

2013 – present   Founding Director of the Institute for Lung Research, Philipps-University Marburg

2011 – present   W3-professorship

2007 – 2011       Head oft the Young Investigator Group FORSYS-Lung, Charité

2003 – 2007       Physician and Medical scientist, Charité Berlin

2003                   Visiting scientist, Johns-Hopkins University

2000 – 2002       Doctoral Scientist, Charité Berlin

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Other Activities

since 2019          Founding Member of the Marburg Center for Precision Medicine

2018 – present   Speaker of BMBF-ERACoSysMed, SysMed-COPD

2017 – present   Vice Speaker of BMBF-JPI AMR

2011 – present   Head of the DZL-Systems Biology Platform

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Awards and Honours

2009                   Research Award of the German Society for Infectiology

2008                   Vocational scholarship, Charité

2003                   Research scholarship, BMBF-CAPNETZ

2000                   Research scholarship, Charité

 

Publications

https://www.ncbi.nlm.nih.gov/pubmed/?term=schmeck+b

 

Ten most important publications

  1. Lindhauer N, Bertrams W, Pöppel A, Herkt C, Wesener A, Hoffmann K, Greene B, van der Linden M, Vilcinskas A, Seidel K, Schmeck B. Antibacterial activity of a Tribolium castaneum defensin in an in vitro infection model of Streptococcus pneumoniae. Virulence 2019

  2. Visekruna A, Hartmann S, Sillke YR, Glauben R, Fischer F, Raifer H, Mollenkopf H, Bertrams W, Schmeck B, Klein M, Pagenstecher A, Lohoff M, Jacob R, Pabst O, Bland PW, Luu M, Romero R, Siegmund B, Rajalingam K, Steinhoff U. Intestinal development and homeostasisrequire activation and apoptosis of diet-reactive T cells. J Clin Invest. 2019

  3. Nandakumar R, Tschismarov R, Meissner F, Prabakaran T, Krissanaprasit A, Farahani E, Zhang BC, Assil S, Martin A, Bertrams W, Holm CK, Ablasser A, Klause T, Thomsen MK,Schmeck B, Howard KA, Henry T, Gothelf KV, Decker T, Paludan SR. Intracellular bacteriaengage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling. Nat Microbiol. 2019

  4. Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LNVogelmeier CF, Lohmeyer J, Schmeck B. Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome. J Infect Dis. 2019

  5. Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B. THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study. Sci Rep. 2017

  6. Jung AL, Herkt CE, Schulz C, Bolte K, Seidel K, Scheller N, Sittka-Stark A, Bertrams W, Schmeck B. Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles. Sci Rep. 2017 Jul 24;7(1):6301.

  7. Wentker P, Eberhardt M, Dreyer FS, Bertrams W, Cantone M, Griss K, Schmeck B, Vera J. An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data. J Immunol. 2017

  8. Du Bois I, Marsico A, Bertrams W, Schweiger MR, Caffrey BE, Sittka-Stark A, Eberhardt M, Vera J, Vingron M, Schmeck B. Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2. J Infect Dis. 2016

  9. Jung AL, Stoiber C, Herkt CE, Schulz C, Bertrams W, Schmeck B. Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages. PLoS Pathog. 2016

  10. Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B. MicroRNAs Constitute a Negative Feedback Loop in Streptococcus pneumoniae-Induced Macrophage Activation. J Infect Dis. 2016

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