Termine, Termine, Termine...
Hier siehst du, was alles demnächst bei uns ansteht. Du bist herzlich eingeladen, bei unseren Treffen vorbeizuschauen! Wir freuen uns auf dich!
Termine, Termine, Termine...
Hier siehst du, was alles demnächst bei uns ansteht. Du bist herzlich eingeladen, bei unseren Treffen vorbeizuschauen! Wir freuen uns auf dich!
Termine, Termine, Termine...
Hier siehst du, was alles demnächst bei uns ansteht. Du bist herzlich eingeladen, bei unseren Treffen vorbeizuschauen! Wir freuen uns auf dich!
Prof. Dr. Bernd Schmeck
Precision Medicine and Targeted Therapy of Inflammatory Diseases
Inflammatory diseases (allergy, autoimmunity, infection, partly malignancies ...) cause a significant morbidity and mortality. New targeted therapies addressing signalling pathways and cell-cell- communication show great promises, but only in specific patient subgroups.
Thus, there is an ongoing urgency for a more targeted and holistic management of the disease, incorporating experimental and clinical multi-OMICS data and the basic principles of P4 medicine (predictive, preventive, personalized, and participatory). I will address the current status and unmet needs regarding precision medicine for patients with inflammatory diseases.
Curriculum vitae
Date of Birth: 19.08.1974
University Education
2007 Habilitation, Humboldt-University Berlin
2002 Dr. med., Humboldt-University Berlin
2000 State examination in Medicine, Justus-Liebig-University Gießen and Humboldt-University Berlin
Employment and Positions
2013 – present Founding Director of the Institute for Lung Research, Philipps-University Marburg
2011 – present W3-professorship
2007 – 2011 Head oft the Young Investigator Group FORSYS-Lung, Charité
2003 – 2007 Physician and Medical scientist, Charité Berlin
2003 Visiting scientist, Johns-Hopkins University
2000 – 2002 Doctoral Scientist, Charité Berlin
Other Activities
since 2019 Founding Member of the Marburg Center for Precision Medicine
2018 – present Speaker of BMBF-ERACoSysMed, SysMed-COPD
2017 – present Vice Speaker of BMBF-JPI AMR
2011 – present Head of the DZL-Systems Biology Platform
Awards and Honours
2009 Research Award of the German Society for Infectiology
2008 Vocational scholarship, Charité
2003 Research scholarship, BMBF-CAPNETZ
2000 Research scholarship, Charité
Publications
https://www.ncbi.nlm.nih.gov/pubmed/?term=schmeck+b
Ten most important publications
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Lindhauer N, Bertrams W, Pöppel A, Herkt C, Wesener A, Hoffmann K, Greene B, van der Linden M, Vilcinskas A, Seidel K, Schmeck B. Antibacterial activity of a Tribolium castaneum defensin in an in vitro infection model of Streptococcus pneumoniae. Virulence 2019
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Visekruna A, Hartmann S, Sillke YR, Glauben R, Fischer F, Raifer H, Mollenkopf H, Bertrams W, Schmeck B, Klein M, Pagenstecher A, Lohoff M, Jacob R, Pabst O, Bland PW, Luu M, Romero R, Siegmund B, Rajalingam K, Steinhoff U. Intestinal development and homeostasisrequire activation and apoptosis of diet-reactive T cells. J Clin Invest. 2019
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Nandakumar R, Tschismarov R, Meissner F, Prabakaran T, Krissanaprasit A, Farahani E, Zhang BC, Assil S, Martin A, Bertrams W, Holm CK, Ablasser A, Klause T, Thomsen MK,Schmeck B, Howard KA, Henry T, Gothelf KV, Decker T, Paludan SR. Intracellular bacteriaengage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling. Nat Microbiol. 2019
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Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LNVogelmeier CF, Lohmeyer J, Schmeck B. Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome. J Infect Dis. 2019
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Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B. THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study. Sci Rep. 2017
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Jung AL, Herkt CE, Schulz C, Bolte K, Seidel K, Scheller N, Sittka-Stark A, Bertrams W, Schmeck B. Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles. Sci Rep. 2017 Jul 24;7(1):6301.
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Wentker P, Eberhardt M, Dreyer FS, Bertrams W, Cantone M, Griss K, Schmeck B, Vera J. An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data. J Immunol. 2017
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Du Bois I, Marsico A, Bertrams W, Schweiger MR, Caffrey BE, Sittka-Stark A, Eberhardt M, Vera J, Vingron M, Schmeck B. Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2. J Infect Dis. 2016
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Jung AL, Stoiber C, Herkt CE, Schulz C, Bertrams W, Schmeck B. Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages. PLoS Pathog. 2016
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Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B. MicroRNAs Constitute a Negative Feedback Loop in Streptococcus pneumoniae-Induced Macrophage Activation. J Infect Dis. 2016